Modeling of malaria vaccine effectiveness ondisease burden and drug resistance in 42 Africancountries

The emergence of antimalarial drug resistance poses a major threat to effective malaria treatment and control. This study aims to inform policymakers and vaccine developers on the potential of an effective malaria vaccine in reducing drug-resistant infections.

Widespread deployment of a malaria vaccine could substantially reduce health
burden in Africa. Maintaining vaccine efficacy longer may be more impactful than a higher initial VE that
falls rapidly.